Firefighters were called to the mosque on Black Cat Rd. around 3:30 Monday morning.
When crews arrived, the west side of the building was on fire, but it quickly spread.
The entire mosque is engulfed in flames.
The Jasper County Sheriff's Office confirmed the fire marshall has already been called in to investigate.
Another fire, which was deemed arson, was reported at the same building July 4th.
Authorities released surveillance video of the suspect, but no arrests have been made.