She was a star of Broadway and the big screen, and won an Academy Award in 1947 for the film "Gentleman's Agreement." She also earned Oscar nominations for her performances in "Come to the Stable" and "All About Eve."
Holm was also seen in dozens of television series, including "Touched by an Angel."
Her family says she passed away peacefully at home, surrounded by family and friends. She was 95.
The latest film in the "Ice Age" franchise gave the box office competition a chill.
The animated "Ice Age: Continental Drift" won the weekend, with an estimated $46-million in ticket sales.
"The Amazing Spider-Man" dropped to second place in its second weekend in theaters. But the superhero remake still caught another $35-million in its web.
And "Ted," the story of a foul-mouthed teddy bear from "Family Guy"-creator Seth Macfarlane, rounded out the top three.
(Nick Valencia for CNN's Hollywood Minute)